Perivascular delivery of Notch 1 siRNA prevents injury-induced Vascular Remodeling.

<p>(A) Representative Verhoeff-van Gieson staining of carotid artery from C57BI6/J mice 14 days after ligation in the absence or presence of scrambled siRNA (ligated) or Ligated+Notch 1 siRNA. White bars mark media area from internal elastic lamina to the external elastic lamina. (B) Carotid artery vessel media, neointima and lumen volumes (evaluated over a 1 mm carotid length) for sham, ligated and Ligated+Notch 1 siRNA groups. (C) Carotid artery Intima/Media ratios for ligated and Ligated+Notch 1 siRNA groups. Data are mean ± SEM, 4 sections analyzed/animal, n = 6 animals for each group.