Loss of <i>Cebpa</i> affects HSC self-renewal.

<p>(A) Expression of <i>Cebpa</i> in different hematopoietic cell populations derived from the HemaExplorer website (<a href="http://servers.binf.ku.dk/hemaexplorer/" target="_blank">http://servers.binf.ku.dk/hemaexplorer/</a>). (B) HSC analysis of <i>Cebpa</i>^fl/fl and <i>Cebpa</i>^Δ/Δ BM. (C) Quantification of the data in (B). <i>Cebpa</i>^fl/fl (n = 7) and <i>Cebpa</i>^Δ/Δ (n = 7). Each panel shows one representative experiment out of three. (D) Survival curves of primary and secondary recipients transplanted with <i>Cebpa</i>^fl/fl (primary: n = 12, secondary: n = 16) and <i>Cebpa</i>^Δ/Δ (primary: n = 16, secondary: n = 17) BM. (E) Contribution of CD45.2 cells to the blood of primary recipients. <i>Cebpa</i>^fl/fl (n = 12) and <i>Cebpa</i>^Δ/Δ (n = 16). (F) Distribution of B, T and myeloid cells in the CD45.2+ blood of primary recipients 16 week after transplantation. (G) BM analysis of primary recipients of <i>Cebpa</i>^fl/fl (n = 8) or <i>Cebpa</i>^Δ/Δ (n = 8) BM cells. Data are represented as mean+SEM, ns designates not significant.