<p>(A) In total, 117 mutational events (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004041#pgen.1004041.s012" target="_blank">Table S1</a>) were identified in 18 sequenced clones resulting in sequence (red) and structural (blue) variation. (B) The number and type of mutations acquired in each individual clones genotyped using aCGH and whole genome sequencing. Non-synonymous SNPs and CNVs are found in most clones.</p
<p>SNPs are shown in black/grey, insertions in red, deletions in blue, and complex variants in orang...
<p>Panel A. Chromosomal location of the genomic alterations observed during the <i>in vitro</i> pass...
(A) Genomes of each replicate population after 50 transfers were sequenced and mapped to the referen...
<p>Mutations in nuclear DNA from the 28 adapted strains from two lineages contained indels, SNPs and...
<p>(A) Total number of mutations in each clone. The two non-hypermutators (T2_F9 and T2_H3) appear o...
a<p>Branch names are denoted in phylogenetic tree in <a href="http://www.plosgenetics.org/article/in...
<p>A) Phylogenetic structure of the cDNA clone population (tree reconstructed using MrBayes). All vi...
<p>(A) A small number of loci are mutated in multiple nitrogen-limited environments. Some loci found...
Summary of mutations identified from sequenced clones taken from transfer 20 (bacterial generation ~...
<p>(A) Number of single nucleotide variants (SNVs) of HKNPC1, GD1, GD2 and AG876 with each genome co...
<p>The mutations present in the <i>hns</i> mutant lineages at day 30 of the passaging period were de...
a<p>See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003736#s4" targe...
<div><p>The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect t...
<p>(A) Mutation prevalences of six mutations in segment 4. (B) Prevalences of the ten associated clo...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
<p>SNPs are shown in black/grey, insertions in red, deletions in blue, and complex variants in orang...
<p>Panel A. Chromosomal location of the genomic alterations observed during the <i>in vitro</i> pass...
(A) Genomes of each replicate population after 50 transfers were sequenced and mapped to the referen...
<p>Mutations in nuclear DNA from the 28 adapted strains from two lineages contained indels, SNPs and...
<p>(A) Total number of mutations in each clone. The two non-hypermutators (T2_F9 and T2_H3) appear o...
a<p>Branch names are denoted in phylogenetic tree in <a href="http://www.plosgenetics.org/article/in...
<p>A) Phylogenetic structure of the cDNA clone population (tree reconstructed using MrBayes). All vi...
<p>(A) A small number of loci are mutated in multiple nitrogen-limited environments. Some loci found...
Summary of mutations identified from sequenced clones taken from transfer 20 (bacterial generation ~...
<p>(A) Number of single nucleotide variants (SNVs) of HKNPC1, GD1, GD2 and AG876 with each genome co...
<p>The mutations present in the <i>hns</i> mutant lineages at day 30 of the passaging period were de...
a<p>See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003736#s4" targe...
<div><p>The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect t...
<p>(A) Mutation prevalences of six mutations in segment 4. (B) Prevalences of the ten associated clo...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
<p>SNPs are shown in black/grey, insertions in red, deletions in blue, and complex variants in orang...
<p>Panel A. Chromosomal location of the genomic alterations observed during the <i>in vitro</i> pass...
(A) Genomes of each replicate population after 50 transfers were sequenced and mapped to the referen...