Extracellular loop of the candidate proteins contain SEA-domains.

<p>(<b>A</b>) Modeled molecular structures of the extracellular domains with striking similarity with SEA-domain. Also shown for comparison is the SEA-domain of mouse TMPRSS2. Typical of SEA-domains, the secondary structure components showed an antiparallel arrangement of β-sheets. A summary of structural models of the entire transcripts in this gene family is shown in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002644#pntd.0002644.s008" target="_blank">Table S1</a>. (<b>B</b>) Rigid body superposition of SjP3842 (blue) over the highest scoring template, PDB: 2e7v (olive). The graph is the Ramachandran plot (φ/ψ) showing conformational angles distribution of the residues. Over 98% of residues were in the favored regions while less than 2% were in the outlier region. (<b>C</b>) Alignments of SjCP3842 with two well defined SEA-domains (human MUC1 and mouse TMPRSS2). Putative SEA-domain consensus cleavage site (red arrow) was identified between β2 and β3.