Intravitreal ASC injection decreased DR related gene expression in diabetic athymic rats.
- Gangaraju Rajashekhar (508120)
- Ahmed Ramadan (508121)
- Chandrika Abburi (508122)
- Breedge Callaghan (508123)
- Dmitry O. Traktuev (508124)
- Carmella Evans-Molina (508125)
- Raj Maturi (508126)
- Alon Harris (508127)
- Timothy S. Kern (189080)
- Keith L. March (508128)
Publication date
January 2014
DOIAbstract
<p>Two months post diabetes induction intravitreal injections of ASC at day 7 were assessed for DR related gene expression changes. Using rat gene specific primers, total RNA was subjected to single step RT-qPCR and results expressed normalized to non-diabetic rats that received saline injection. Note a significant increase in genes implicated in DR in diabetic athymic nude rats that received saline. A single intravitreal injection of ASC at day 7 significantly downregulated these genes compared to diabetic retina. Data are from n = 6–8 rats per group. *p<0.05.</p
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