Disruption of MF terminal organization in FAD mutant.

<p>(A and B) Representative reconstructions of MF terminal structures from WT (A) and FAD mutant (B); axons (royal blue), vesicle containing DG-CA3 boutons (sky blue), filopodia (orange), vesicle containing DG-INT boutons (green), scale bar = 2 µm. (C) Quantification of DG-CA3 MFB volume for WT boutons (n = 16) and FAD boutons only onto TE spines (n = 25) and all boutons onto CA3 (n = 41). (D) Number of TE spines synapsed onto per MF terminal complex. (E) Relative proportion MF terminal, vesicle containing boutons synapsing onto interneuron, CA3 shaft and CA3 TE spine targets. (F) Number of DG-INT boutons per MF terminal complex. (G) Number of filopodia per MF terminal complex. *p<0.05; ***p<0.001, by t-test, error bars represent ±SEM. For per complex analysis: WT, n = 19; FAD, n = 21.