Overexpression of Cav-1 was frequently found in HCC tissues, which predicted poor prognosis of HCCs after liver resection.

<p>(A) The representative IHC staining of Cav-1 in HCC tissues (a) and adjacent normal tissues (b). There was Cav-1 protein expressing in both cell membrane (as labelled by black arrows) and cytoplasm (as labelled by a white arrow); (B) The representative IHC staining of GLI1 in HCC tissues (a) and adjacent normal tissues (b). Most of GLI1 protein located in cell nucleus, as shown by black arrow head; (C) The negative control staining in HCC tissues (a) and adjacent liver tissues (b); (D) HCC patients with higher level of Cav-1 had the worse prognosis after hepatic resection than ones with lower level of Cav-1 (HR = 4.49, P<0.0001).