<p>Serum from rats dosed with 30, 45 or 60/kg of anti-Her2 Cys-ADC or 30, 60 or 90 mg/kg of anti-Her2 position 1-ADC were collected and the total amount of antibody (TAb) or ADC was measured via ELISA. (A) The pharmacokinetic profile of the anti-Her2 Cys-ADC was evaluated. (B) The pharmacokinetic profile of the anti-Her2 position 1-ADC was evaluated.</p
Exposure to chemicals may have an influence on the immune system. Often, this is an unwanted effect ...
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selec...
Abstract. -BACKGROUND AND AIM: Probe drugs have been widely used to assess the activities of various...
<p>Serum from rats dosed with 30, 45 or 60 mg/kg of anti-Her2 Cys-ADC or 30, 60 or 90 mg/kg of anti-...
<p>Comparison of selected serum chemistry parameters (Day 15) between cysteine and site specifically...
<p>Rat body weights were measured post single dose, i.v. administration of 30 or 60/kg of the anti-H...
Serum concentrations of human IgG1 (A1-D1) and IgG2 (A2-D2) antibodies over time were determined aft...
Pharmacokinetic parameters were determined for the IgG1 (A1-D1) and IgG2 (A2-D2) antibody panels aft...
The ratio of the pharmacokinetic parameters comparing NHPs to rats after subcutaneous administration...
The ratio of the pharmacokinetic parameters of human IgG1 to the human IgG2 antibodies with matched ...
<p>At t = 0 hAd was dosed i.v. at 4.1 mg/kg (open circles), i.p. at 4.1 mg/kg (open triangles) or i....
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selec...
For antibody drug conjugates (ADCs), the fate of the cytotoxic payload in vivo needs to be well unde...
(A) G418 and gentamicin X2 were administered by subcutaneous injection to rats at a dose of 10 mg/kg...
ABSTRACTA humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificit...
Exposure to chemicals may have an influence on the immune system. Often, this is an unwanted effect ...
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selec...
Abstract. -BACKGROUND AND AIM: Probe drugs have been widely used to assess the activities of various...
<p>Serum from rats dosed with 30, 45 or 60 mg/kg of anti-Her2 Cys-ADC or 30, 60 or 90 mg/kg of anti-...
<p>Comparison of selected serum chemistry parameters (Day 15) between cysteine and site specifically...
<p>Rat body weights were measured post single dose, i.v. administration of 30 or 60/kg of the anti-H...
Serum concentrations of human IgG1 (A1-D1) and IgG2 (A2-D2) antibodies over time were determined aft...
Pharmacokinetic parameters were determined for the IgG1 (A1-D1) and IgG2 (A2-D2) antibody panels aft...
The ratio of the pharmacokinetic parameters comparing NHPs to rats after subcutaneous administration...
The ratio of the pharmacokinetic parameters of human IgG1 to the human IgG2 antibodies with matched ...
<p>At t = 0 hAd was dosed i.v. at 4.1 mg/kg (open circles), i.p. at 4.1 mg/kg (open triangles) or i....
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selec...
For antibody drug conjugates (ADCs), the fate of the cytotoxic payload in vivo needs to be well unde...
(A) G418 and gentamicin X2 were administered by subcutaneous injection to rats at a dose of 10 mg/kg...
ABSTRACTA humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificit...
Exposure to chemicals may have an influence on the immune system. Often, this is an unwanted effect ...
Antibody drug conjugates (ADCs) are monoclonal antibodies designed to deliver a cytotoxic drug selec...
Abstract. -BACKGROUND AND AIM: Probe drugs have been widely used to assess the activities of various...