Nlrp3 deficiency does not affect myofibroblast accumulation and collagen deposition following UUO.

<p>Renal myofibroblast accumulation (A) and collagen deposition (B) in obstructed and contralateral kidneys of wild type (white bars) and Nlrp3−/− (black bars) mice following UUO. Nlrp3 deficiency did not affect the accumulation of myofibroblasts in kidneys following UUO (A). Except for a difference observed at 3 days post-UUO Nlrp3 deficiency did not influence renal collagen deposition following UUO (B). Data are mean±SEM of 7 mice per group. Contral. = contralateral kidneys of mice subjected to 14 days of UUO. *:p<0.05. The panels show representative microphotographs of renal tissue of mice subjected to 14 days of UUO, magnification x200.