MK801-induced antidepressant-like behavioral effects in the FST.

<p>MK801-induced immobility and swimming time in C57BL/6N mice (A,B) and in mice lacking NMDAR specifically in PV neurons (PV-Cre+/NR1f/f, <i>red bars</i>) compared with control (NR1f/f, <i>black bars</i>) (C,D). (A) Immobility of C57BL/6N mice in repeated FST 30 min, 24 h and 1 week after acute treatment with 0.1 mg/kg MK801 (<i>white bars</i>, n = 10) or water (<i>black bars</i>, n = 10). MK801 induces rapid antidepressant-like responses to a lesser extent than ketamine 30 min after treatment. The antidepressant effect of MK801 is abolished 24 h and 1 week after treatment. MK801-induced immobility time is: 220±3 water and 171±17 MK801 (30 min) (p<0.05 Student's t-test); 224±5 water and 223±3 MK801 (24 h) (p>0.05 Student's t-test); 197±10 water and 215±7 MK801 (1 week) (p>0.05 Student's t-test). (B) Swimming scored in the experiment in (A). MK801-induced swimming time is: 20±3 water and 68±17 MK801 (30 min) (p<0.05 Student's t-test); 15±4 water and 16±3 MK801 (24 h) (p>0.05 Student's t-test); 42±10 water and 24±7 MK801 (1week) (p>0.05 Student's t-test). (C) Immobility of PV-Cre+/NR1f/f (<i>red bars</i>) and NR1f/f (<i>black bars</i>) mice in repeated FST 30 min and 24 h after acute treatment with 0.1 mg/kg MK801. Immobility time 30 min and 24 h after MK801 is: 65±16 and 104±13 (NR1f/f <i>black bars</i>, n = 13); 54±16 and 103±16 (PV-Cre+/NR1f/f <i>red bars</i>, n = 14), respectively. (D) Swimming scored in the experiment in (C). Swimming time 30 min and 24 h after MK801 is: 168±15 and 135±16 (NR1f/f <i>black bars</i>, n = 13); 183±15 and 130±14 (PV-Cre+/NR1f/f <i>red bars</i>, n = 14), respectively. All time points p>0,05 (Student's t-test). Both genotypes display similar behavioral response to the MK801 treatment. Results (sec/4 min) are presented as mean values ±SEM.