KSHV infection is restricted by PML and Sp100 but not ATRX.

<p><b>A</b>: Equal numbers of HFF cells treated with siRNAs against ATRX (siATRX), PML (siPML), Sp100 (siSp100), Daxx (siDAXX) and control (siC), were infected with equal amounts of KSHV. GFP-expression was measured two days post infection by flow-cytometry. <b>B</b>: Mean value of at least 3 individual infection experiments according to A. Statistical analyses were conducted with GraphPad Prism 6 using the paired t test for siC and siSP100, siPML and siDAXX, respectively. **p<0.015; *** p<0.0001. <b>C</b>: Equal numbers of HFF cells treated with siRNAs against PML and control (siC) were infected with equal amounts of KSHV Bac16 wt and HVS Bac43 wt virus and the GFP-expression was measured two days post infection by flow-cytometry.