Computational model description.

<p>(A) The model includes three different cell types: stem, progenitor and differentiated. All cell types interact with the microenvironment in the form of oxygen tension. (B) The behaviour of each cell type is captured by a flowchart. The last segment with discontinuous arrows represents behaviour that is specific to the stem cells. (C) The cells are represented as agents inhabiting points in a grid in a 2D space with 500×500 grid points. Stem cells are represented as red points, progenitor as green and fully differentiated as blue. The vasculature is represented as oxygen source points in black.