Heterozygosity and historical changes in effective population size.

<p>(A) Box plots of heterozygosity measured in 5000 100 kb windows for each sample. (B) Reconstruction of historical patterns of effective population size (N_e) for individual genome sequences. Based upon the genomic distribution of heterozygous sites using the pairwise sequential Markovian coalescent (PSMC) method of Li and Durbin 2011 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004016#pgen.1004016-Li2" target="_blank">[20]</a>. Time scale on the x-axis is calculated assuming a mutation rate of 1×10⁻⁸ per generation (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004016#pgen.1004016.s027" target="_blank">Text S8</a>); estimates from the full data and 50 bootstraps are depicted by darker and lighter lines, respectively.