A protein alpha-helix is defined by 3.6 amino acids per turn. Cyclization of the tripeptide Alanine-Leucine-Glutamate through a side chain to the N-terminus lactam bond produces cyclo-(1,3)-[ALE]-NH(2) which displays a circular dichroism spectrum typical of an alpha-helix backbone. However, proton NMR spectra show a novel cyclic peptide featuring two non-hydrogen-bonded antiparallel beta-strands connected by an Ala-Leu cis-amide bond. This example highlights that the common practice of characterizing alpha-helices by CD spectra alone can be misleading
The two peptides, rich in Ca-tetrasubstituted amino acids, Ac-[Aib-L-(aMe)Val-Aib]2-L-His-NH2 (1) an...
Alpha helices are useful scaffolds to build biologically active peptides. The intrinsic stability of...
Left or right handed alpha helicity can be induced in a pentapeptide (ANGYG) by appending left or ri...
The CD spectra of the peptides $Boc-X-{(Aib-X)}_n-OMe$ (n = 1,2,3) and $Boc-{(Aib-X)}_5-OMe$, where ...
Non protein amino acids with strong secondary structure preferences are potentially useful in peptid...
The decapeptides $Boc-Aib-L-Val-Aib-Aib-{(L-Val)}_3-Aib-L-Val-Aib-OMe$ and $Boc-Aib-L-Leu- Aib-Aib-{...
Two centrally positioned alpha-aminoisobutyryl (Aib) residues have been used to stabilize distinct h...
The crystal-state preferred conformations of two tripeptides, one tetrapeptide, and one pentapeptide...
As an attempt to find out how the sequence length determine the alpha-helix formation, seven peptide...
Vass E, Strijowski U, Wollschlaeger K, et al. VCD studies on cyclic peptides assembled from L-alpha-...
We have synthesized by solution methods and fully characterized the N-alpha-blocked heptapeptide met...
The stabilization of helical structures in short apolar peptides is readily achieved by introduction...
Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X = Ala, 1; Arg, 2) in water adopt one alpha-...
The conformational properties of , -dialkylated amino acid residues possessing acyclic (diethylglyc...
The conformational characteristics of three hexapeptides Boc-Leu-Xxx-Val-Leu-Aib-Val-OMe(Xxx = Ala 1...
The two peptides, rich in Ca-tetrasubstituted amino acids, Ac-[Aib-L-(aMe)Val-Aib]2-L-His-NH2 (1) an...
Alpha helices are useful scaffolds to build biologically active peptides. The intrinsic stability of...
Left or right handed alpha helicity can be induced in a pentapeptide (ANGYG) by appending left or ri...
The CD spectra of the peptides $Boc-X-{(Aib-X)}_n-OMe$ (n = 1,2,3) and $Boc-{(Aib-X)}_5-OMe$, where ...
Non protein amino acids with strong secondary structure preferences are potentially useful in peptid...
The decapeptides $Boc-Aib-L-Val-Aib-Aib-{(L-Val)}_3-Aib-L-Val-Aib-OMe$ and $Boc-Aib-L-Leu- Aib-Aib-{...
Two centrally positioned alpha-aminoisobutyryl (Aib) residues have been used to stabilize distinct h...
The crystal-state preferred conformations of two tripeptides, one tetrapeptide, and one pentapeptide...
As an attempt to find out how the sequence length determine the alpha-helix formation, seven peptide...
Vass E, Strijowski U, Wollschlaeger K, et al. VCD studies on cyclic peptides assembled from L-alpha-...
We have synthesized by solution methods and fully characterized the N-alpha-blocked heptapeptide met...
The stabilization of helical structures in short apolar peptides is readily achieved by introduction...
Cyclic pentapeptides (e.g. Ac-(cyclo-1,5)-[KAXAD]-NH2; X = Ala, 1; Arg, 2) in water adopt one alpha-...
The conformational properties of , -dialkylated amino acid residues possessing acyclic (diethylglyc...
The conformational characteristics of three hexapeptides Boc-Leu-Xxx-Val-Leu-Aib-Val-OMe(Xxx = Ala 1...
The two peptides, rich in Ca-tetrasubstituted amino acids, Ac-[Aib-L-(aMe)Val-Aib]2-L-His-NH2 (1) an...
Alpha helices are useful scaffolds to build biologically active peptides. The intrinsic stability of...
Left or right handed alpha helicity can be induced in a pentapeptide (ANGYG) by appending left or ri...