The functional analysis of ADAM-12-L and -S in H345 cells.

<p>(A) The mRNA expressions of ADAM-12-L and -S were detected by real time PCR in H345 cells transfected with the expression vector of ADAM-12-L and -S, ** <i>P</i><0.01. Mock: untreated group; pcDNA3.1: negative group. 12-L: transfected with pcDNA3.1-ADAM-12-L; 12-S: transfected with pcDNA3.1-ADAM-12-S. (B) The cells induced by the filtering chamber membrane were not significantly different in the H345 cells transfected with pcDNA3.1-ADAM-12-L (named H345-L), however the cells were significantly increased in H345 cells transfected with pcDNA3.1-ADAM-12-S (named H345-S), * <i>P</i><0.05. (C) ADAM-12-L induced cells to go from the G0-G1 phase into the S phase, but ADAM-12-S did not influence cellular proliferation in H345 cells.