<i>LMO2</i> and <i>HHEX</i> are co-expressed in ETP-ALL.

<p>(<b>A</b>) The heat map shows a supervised clustering result based on <i>LMO2</i> (left panel) and <i>HHEX</i> (right panel) expression. The colors denote z scores ranging from −4 to 4. The gene expression dataset of 78 pediatric T-ALLs was analyzed by <i>Limma</i> based on a discrete cutoff of median <i>LMO2</i> and <i>HHEX</i> expression. The black arrows show 12 Early T-cell Precursor ALL cases. <i>LYL1</i>, <i>HHEX</i>, <i>MEF2C</i>, and <i>MYCN</i> genes were concordantly expressed with <i>LMO2</i> and <i>HHEX</i>. These genes were expressed highest in the ETP-ALL cases. A full version of the heat maps are in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085883#pone.0085883.s001" target="_blank">file S1</a>. (B) Survival analysis was performed on LMO2-high versus LMO2-low T-ALL and on HHEX-high v. HHEX-low T-ALLs. The curves for <i>LMO2</i> classes in the left panel were not statistically significant (<i>P = .19</i>) but the curves for <i>HHEX</i> classes were significantly different (<i>P = .03</i>) by Log rank tests.