Systemic inflammation is decreased in <i>Sharpin^cpdm-Dem</i>, <i>Rag1^−/−</i> double mutant mice but significantly increased in <i>Sharpin^cpdm-Dem</i>, <i>Il4ra^−/−</i> double mutants compared to <i>Sharpin^cpdm-Dem</i> and WT controls.

<p>Four representative histological comparisons of systemic inflammation in liver adrenal glands and lungs and lymphoid architecture in Peyer's patches in four week old WT (A,G,M,S), <i>Sharpin^cpdm-Dem</i> (B,H,N,T); <i>Rag1^−/−</i>(C,I,O,U); <i>Il4ra</i>^−/− (E,K,Q,W); <i>Sharpin^cpdm-Dem, Rag1^−/−</i> (D,J,P,V); and <i>Sharpin^cpdm-Dem, Il4ra</i>^−/− (f,l,r,x) mice. Systemic inflammation is generally attenuated in <i>Sharpin^cpdm-Dem, Rag1^−/−</i> double mutant mice but exacerbated in <i>Sharpin^cpdm-Dem</i>, <i>Il4ra</i>^−/− double mutant mice compared to <i>Sharpin^cpdm-Dem</i> controls.