Cigarette smoke exposure suppressed the production of cytokines at later time point of pdmH1N1 infection.

<p>The mice were exposed to room air or cigarette smoke for 21 days and then infected with pdmH1N1 virus. The lungs were collected on day 1, 3 and 5 after pdmH1N1 infection. A) The production of cytokines. B) The production of chemokines. Results represent mean ± SEM of 4–10 mice per group. Data are representative of two independent experiments. ^#<i>p</i><0.05, ^##<i>p</i><0.01; ^###<i>p</i><0.001 were tested by ANOVA of four groups; *<i>p</i><0.05; **<i>p</i><0.01; ***<i>p</i><0.001 were determined by Tukey post hoc test.