Resveratrol decreases proliferation of Cisplatin-sensitive A2780 cells but not Cisplatin-resistant A2780CP cells.

<p>MTT assay was performed to evaluate A2780 and A2780 cell lines proliferation in response to 10 µM Cisplatin and increasing doses up to 60 µM of Resveratrol. A2780 cells proliferation was increased by Resveratrol at 20 µM and decreased at 60 µM while all doses suggest an increase in proliferation in A2780CP cells. Resveratrol also potentiates Cisplatin decrease of proliferation in A2780 cells. Graph bars with different letters are statistically different (p<0.05). In graphs, mock: untreated cells, R20: Resveratrol 20 µM, R40: Resveratrol 40 µM, R60: Resveratrol 60 µM, CP: Cisplatin, R20CP: Resv. 20 µM + Cisplatin, R40CP: Resv. 40 µM + Cisplatin, R60CP: Resv. 60 µM + Cisplatin.