<p>The biodistribution of the MSA-Alexa700 over time in animals IP injected with stressed (red line) and unstressed (black line) formulations. The accumulation of fluorescent signal is expressed as percent of injected dose per gram of tissue (% ID/g tissue) or percent of injected dose per ml of plasma or urine (% ID/ml).</p
<p>Plasma was collected over a period of 15 minutes—48 hours after M10 injection and measured by ind...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
(A) Calculated ratio of Alexa594-BSA (background corrected) and Clta-eGFP signal at the apical area ...
<p>A) <i>In vivo</i> distribution of fluorescence signal from MSA-Alexa700 conjugates upon injection...
<p>Distribution of fluorescence signal in different organs 48 p.i. via IV, IM, IP and SC routes. The...
<p>A) IV injection of stressed MSA-Alexa700 resulted in the formation of fluorescent “hotspots” in t...
<p>Data are presented as % injected dose per gram. Each value represents the mean±S.D. for 3 animals...
<p>Data are presented as the mean (± SEM) percent injected dose per gram (%ID/g) for selected tissue...
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Biodistribution of NPs following tail vein injection in mice at 1 hour (n = 3).</p
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
<p><b>A.</b> Biodistribution of <sup>64</sup>Cu-NOTA-TRC105 and <sup>64</sup>Cu-DOTA-TRC105 at 24 h ...
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
<p>Plasma was collected over a period of 15 minutes—48 hours after M10 injection and measured by ind...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
(A) Calculated ratio of Alexa594-BSA (background corrected) and Clta-eGFP signal at the apical area ...
<p>A) <i>In vivo</i> distribution of fluorescence signal from MSA-Alexa700 conjugates upon injection...
<p>Distribution of fluorescence signal in different organs 48 p.i. via IV, IM, IP and SC routes. The...
<p>A) IV injection of stressed MSA-Alexa700 resulted in the formation of fluorescent “hotspots” in t...
<p>Data are presented as % injected dose per gram. Each value represents the mean±S.D. for 3 animals...
<p>Data are presented as the mean (± SEM) percent injected dose per gram (%ID/g) for selected tissue...
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Biodistribution of NPs following tail vein injection in mice at 1 hour (n = 3).</p
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
<p><b>A.</b> Biodistribution of <sup>64</sup>Cu-NOTA-TRC105 and <sup>64</sup>Cu-DOTA-TRC105 at 24 h ...
Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-d...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
<p>Plasma was collected over a period of 15 minutes—48 hours after M10 injection and measured by ind...
<p>Data are presented as % injected dose per gram. Each value represents the mean ± s.d. for 3 anima...
(A) Calculated ratio of Alexa594-BSA (background corrected) and Clta-eGFP signal at the apical area ...