Microvasculatures observed at different levels of collagen density.

<p>Increasing the density of the ECM reduced neovascularization in both the experiments and computational simulations. Top Row: Z-projection mosaic of 3D confocal image data showing vascularized collagen gels taken at Day 6 of growth. Bottom Row: Results of the comparable computational simulations, presented as 3D volume-renderings of the line segment data. The three levels of collagen density assessed in this study were: 2.0 mg/ml (A, D), 3.0 mg/ml (B, E), and 4.0 mg/ml (C, F). (Scale bar = 350 µm).