Comparison of the effects of running wheels and running discs on adult neurogenesis.

<p><b>A</b>, The Wheel versus Disc experiment. Mice were maintained for 4 weeks in one of five housing conditions: Empty, Locked wheel, Running wheel, Locked disc and Running disc. <b>B</b>, Comparison of average daily running distances on Running Wheels and Running Discs. Note that average running distances were about 80% higher on Discs than on Wheels. <b>C–E</b>, Quantifications of the numbers of <b>C</b>, Ki67⁺ proliferating cells, <b>D</b>, NeuroD⁺ neuroblasts and <b>E</b>, Calretinin⁺ maturing post-mitotic neurons. In all cases, there was no significant difference between the Control, Locked wheel and Locked disc groups, or between the Running wheel and Running disc groups (t-tests). DG = Dentate Gyri.