Autologous neutralizing activity elicited by the VC10042-derived Envs.

<p>(A) Neutralization of VC10042 viruses by VC10042 plasma. Values reported are the reciprocal IC50 titers, which have been reported previously elsewhere <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086905#pone.0086905-Sather2" target="_blank">[35]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086905#pone.0086905-Diskin2" target="_blank">[52]</a>. (B) Neutralization activity of immune serum to VC10042 autologous isolates. The value reported is the percent neutralization at a serum dilution of 1∶10, minus three times any MLV activity. Greater than 10% neutralization was recorded and the values are heat map color-coded. (2A) = adjuvant supplied at only the first two immunizations; (4A) = adjuvant supplied at all four immunizations; trimer = animals immunized with trimer; mono = animals immunized with monomer; (−) = no neutralization was observed.