Immunohistochemical staining of PTPN12 protein in HCC and noncancerous liver tissues.

<p><b>A.</b> Normal expression of PTPN12 was observed in a HCC case, showing strong diffuse cytoplasmic immunoreactivity of PTPN12 (upper panel, ×100; lower panel, ×400). <b>B.</b> A HCC case showed decreased expression of PTPN12, in which all of cancer cells showed weak staining of PTN12 (upper panel, ×100; lower panel, ×400). <b>C.</b> Negative expression of PTPN12 was detected in a HCC case (upper panel, ×100; lower panel, ×400). D. Normal expression of PTPN12 was observed in adjacent liver tissues, in which all of cancer cells showed strong staining of PTPN12 (upper panel, ×100; lower panel, ×400).