Secreted sACE expressing mice cannot maintain normal blood pressure.

<p><b><i>A</i></b> The systolic blood pressure of age-matched adult mice (Ace-/-, Ace+/+, Ace+/− and TeS, as indicated) was measured using non-invasive, computerized tail-cuff plethysmography method. The systolic blood pressure (in mm Hg) was calculated using the mean daily blood pressure over a five day reading period (the number of mice is indicated as <i>n</i>; * <i>p</i><0.001 Ace+/− <i>vs</i> Ace-/- TeS/TeS). <b><i>B</i></b> Ace+/− and Ace-/- TeS/TeS (TeS) mice were subjected to radiotelemetric analyses for measurement of both systolic (SBP and diastolic blood pressure (DBP) (described in Experimental Procedures) and a mean blood pressure is represented for each group of mice (n, the number of mice from each group; * <i>p</i><0.001 Ace+/− <i>vs</i> Ace-/- TeS/TeS).