Protein interfaces and interface clusters based on years.

<p>(a) Protein interface and interface clusters evaluation during years. (b) Distribution of protein interface cluster sizes throughout years. While the number of protein interface clusters is increasing, the cluster sizes are getting denser. The largest cluster in 1999 had 238 members that increased to 1361 in 2011. The minimum cluster size criterion is used to stop the algorithm in order to prevent the network nodes as network size of 1. During separation of the networks, for example, if one of the networks divided into two networks which have 4 and 6 nodes respectively, the algorithm only tries to divide the network which is above 5 (if it is possible) because the other network reached its final state according to our stopping criterion.