Absence of PAR1 signalling on BM-derived cells can confer protection against liver fibrosis.

<p>C57/BL6 WT mice transplanted with BM from PAR1 knockout donors (PAR1(−/−)BMT, D–F) acquired significantly less hepatic collagen (images A&D, sirius red, ×100; graph G), fewer activated myofibroblasts (images B&E, αSMA, brown, ×100; graph H) and fewer hepatic macrophages (images C&F, F4/80, brown, ×200; graph I) after CCl₄ injury compared to control mice transplanted with WT BM from C57/BL6 donors (WTBMT, A–C). (graphs show mean + SEM, p values as shown.)