TRP2 and p53 expression in melanoma tissue.

<p>(A) Representative immunohistochemical staining for TRP2 and p53 in consecutive sections of a primary melanoma; scale bars: upper panel 1 mm, lower panel 100 µm. (B) Linear regression analysis of p53 and TRP2 histology scores derived from the analysis of 172 melanomas (139 primary and 33 metastatic melanoma) evaluated by a histopathologist. Staining intensity was scored between 0 and 3 and the extent of positivity between 0 and 4. By multiplying both values a minimum score of 0 and a maximum of 12 was derived; linear regression analysis comparing p53 and TRP2 histology scores revealed borderline-significant (p = 0,352) positive correlation and a coefficient of determination (R²) of 0,0258. (C) Since the number of individual dots in B cannot be visualized the distribution of individual p53 and TRP2 histology scores are displayed in the table.