Areas of gray matter atrophy associated with epilepsy duration in TLE-HS and TLE-NL.

<p>Both groups of patients had areas of GM atrophy associated with epilepsy duration. In TLE-HS, the duration of epilepsy was correlated with GM atrophy, mainly in the bilateral anterior and lateral temporal lobes (A), while in TLE-NL it was more pronounced in bilateral precentral areas and contralateral insula (B) (Multiple regression, p<0.001, uncorrected, minimum threshold cluster of 30 voxels). TLE-HS: temporal lobe epilepsy with MRI signs of hippocampal sclerosis; TLE-NL: temporal lobe epilepsy with normal MRI; T: t-value; L: left; R: right.