Pharmacological property of I<sub>HERG</sub> reported by AP-clamp.
- Pen Zhang (515304)
- Ping Guan (515305)
- Xiao-Lu Bai (515306)
- Zhi-Ping Song (515307)
Publication date
January 2014
DOIAbstract
<p><b><i>A</i></b>, effects of I<sub>Kr</sub>/HERG blocker dofetilide (Dof, 10 nM) on I<sub>HERG</sub> with AP waveforms of various regions. *<i>p</i><0.05 <i>vs.</i> Ctl (n = 18 cells). <b><i>B</i></b>, % block of I<sub>HERG</sub> over control by dofetilide with AP waveforms of various regions. *<i>p</i><0.05 <i>vs.</i> Endo-AP (n = 18 cells). <b><i>C</i></b>, Fold difference of I<sub>HERG</sub> blockade by dofetilide with AP waveforms of various regions. Data were normalized to the value with Epi-AP.</p
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