Time course of vascular parameters.

<p>A–E represent parameters calculated for medium vessels from morphometric analysis, while F is calculated for small vessels from densitometric analysis. In morphometric analysis, VV/TV of medium vessels, VS/TV, V.Th, and V.Sp of ligated paws exhibited significant differences on day 2 with respect to pre-surgery sham and control values. In the densitometric analysis, V.D of small vessels of ligated paws also exhibited a significant difference with respect to pre-surgery sham and control values. *p<0.05. N = 12 for ligated group, N = 4 for sham-operated group, and N = 7 for control group (from reproducibility study).