Immunohistochemical staining and scoring analysis of HIC-1 in breast cancer tissues and adjacent normal breast tissue.

<p>A. HIC-1 protein expression was decreased in breast cancer tissue (400×). B. The expression of HIC-1 protein was strong in normal breast epithelial tissue (400×). C. Bar chart of immunohistochemical scores. Normal breast epithelial tissue scored 8.2±1.75 points, whereas the average score of breast cancer was 3.54±1.46. There were significant differences between the two groups (<i>P</i><0.001). D. The expression of HIC-1 was higher in younger patients compared with older patients (<i>P</i><0.05).