<p>Sections of lungs from <i>Braf<sup>CA/+</sup></i> mice infected with LEX-iCL lentiviruses expressing EGFP, KRAS<sup>V12</sup> or the indicated KRAS<sup>V12/ED</sup> mutants. Slides were stained with haematoxylin and eosin and are shown at low (upper panels) and high (lower panels) magnification. The box in the upper panels depicts region shown at higher power. All images are representative for each lentiviral construct. Bars, 3 mm.</p
<p>Hematoxylin and eosin staining of histological sections showing lung hyperplasia in Tyr::<i>Cre</...
<p>(<b>A</b>) RT-PCR amplification of <i>Flag-KRAS</i>, <i>Flag-HRAS</i>, <i>p110CAAX</i> and <i>GAP...
<p>Tumor size was measured by section area at 16 weeks post-infection along with Cre-mediated activa...
Lung cancer is currently the most deadly malignancy in industrialized countries and accounts for 18 ...
Lung cancer is the most prevalent malignancy in the industrialized world and is responsible for ~160...
Lung cancer is currently the most deadly malignancy in industrialized countries and accounts for 18%...
<p>A, B. PAS and hematoxylin staining of lung adenomas typical of CK19<sup>CreERT</sup>; LSL-Kras<su...
<p><i>Braf<sup>CA/+</sup></i> mice were infected with as indicated and tumor size vs. proliferation ...
Lung cancer is currently the most deadly malignancy in Canada, accounting for 27% of all cancer-rela...
<p>Six to eight week old LSL-<i>Kras, Rb1</i><sup><i>+/+</i></sup> and LSL-<i>Kras, Rb1</i><sup>∆L/∆...
<p>(<b>A</b>) PCR amplification of genomic DNA yielding a 621 bp or 517bp fragment indicative of the...
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of ger...
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of ger...
Mutations in the Kirsten Ras 1 (KRAS) and V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) gene...
Mutationally activated BRAF(V600E) (BRAF(VE)) is detected in similar to 6% of human malignancies...
<p>Hematoxylin and eosin staining of histological sections showing lung hyperplasia in Tyr::<i>Cre</...
<p>(<b>A</b>) RT-PCR amplification of <i>Flag-KRAS</i>, <i>Flag-HRAS</i>, <i>p110CAAX</i> and <i>GAP...
<p>Tumor size was measured by section area at 16 weeks post-infection along with Cre-mediated activa...
Lung cancer is currently the most deadly malignancy in industrialized countries and accounts for 18 ...
Lung cancer is the most prevalent malignancy in the industrialized world and is responsible for ~160...
Lung cancer is currently the most deadly malignancy in industrialized countries and accounts for 18%...
<p>A, B. PAS and hematoxylin staining of lung adenomas typical of CK19<sup>CreERT</sup>; LSL-Kras<su...
<p><i>Braf<sup>CA/+</sup></i> mice were infected with as indicated and tumor size vs. proliferation ...
Lung cancer is currently the most deadly malignancy in Canada, accounting for 27% of all cancer-rela...
<p>Six to eight week old LSL-<i>Kras, Rb1</i><sup><i>+/+</i></sup> and LSL-<i>Kras, Rb1</i><sup>∆L/∆...
<p>(<b>A</b>) PCR amplification of genomic DNA yielding a 621 bp or 517bp fragment indicative of the...
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of ger...
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of ger...
Mutations in the Kirsten Ras 1 (KRAS) and V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) gene...
Mutationally activated BRAF(V600E) (BRAF(VE)) is detected in similar to 6% of human malignancies...
<p>Hematoxylin and eosin staining of histological sections showing lung hyperplasia in Tyr::<i>Cre</...
<p>(<b>A</b>) RT-PCR amplification of <i>Flag-KRAS</i>, <i>Flag-HRAS</i>, <i>p110CAAX</i> and <i>GAP...
<p>Tumor size was measured by section area at 16 weeks post-infection along with Cre-mediated activa...