IGF-1R and IGF-1 expression and the effect of IGF-1 on growth in cHL cell lines.

<p>A, Western blot showing expression of IGF-1R in L428, KM-H2 and L1236. The IGF-1R level was high in L428, moderate in L1236 and low in KM-H2. B, IGF1 protein levels in the culture supernatant of cHL cell lines. The IGF-1 protein levels were similar in the three cHL cell lines. C, IGF-1 treatment of L428 cells revealed a significant effect on cell growth. D, L1236 cells showed a significant effect on cell growth upon IGF-1 treatment. E, no effect was seen in KM-H2 cells upon treatment with IGF-1.