Chronic <i>H. hepaticus</i> infection plus anti-IL10R mAb treatment induces colitis in pIV−/− K14 CIITA Tg mice.

<p>(A) Development of body weight during anti-IL-10R mAb or isotype treatment of <i>H. hepaticus</i>-infected pIV−/− K14 CIITA Tg mice or pIV+/− K14 CIITA Tg controls (<i>n = </i>9–11 per group). (B) Serum albumin concentrations in feces collected on days 26–30 (<i>n = </i>6–8 per group). Data are shown as mean and s.d. and represent two pooled experiments. (C–D) Colon histopathological analysis on day 32; (C) colitis scores, data displayed as mean, and (D) representative photomicrographs of colon sections, stained with hematoxylin and eosin. Bar, 100 µm. Data represent three pooled experiments (<i>n = </i>9–11 per group). αIL10R, anti-interleukin-10 receptor monoclonal antibodies;