Distribution of correlations between microarray and sequencing profiles for miRNA and gene expression.

<p>(A) Histogram of correlation coefficients for individual miRNAs measured by miRNA-Seq and miRNA array. (B) Histogram of correlation coefficients for mRNAs profiled by Illumina HiSeq and mRNA array. (C) The empirical cumulative distribution function (ECDF) of the correlation between array and sequencing for miRNA (black), filtered miRNA (color) and mRNA (gray) measurements. Nearly, 72% of miRNAs demonstrate a correlation coefficient ≤0.5 whereas 22% of RNAs have a correlation coefficient ≤0.5. When filtered based on expression level, the percentage of miRNAs with correlation ≤0.5 saturated to 56%.