Functional clustering of genes involved in energy metabolism (amiodarone).

<p>Genes related to energy metabolism identified by GSEA as being significantly altered upon amiodarone (AMI) treatment were subjected to functional clustering in STRING. Functional clusters such as lipid synthesis, β-oxidation, mitochondria, peroxisomes, and PPARα -dependent lipid metabolism were identified. Information about fold change (FC = treatment vs. control) for the analysed genes in individual mice is presented as a heat map. Genes that did not form connected nodes were removed from the presented clusters. Thicker lines represent stronger associations between genes. Inter-cluster edges are represented by dashed-lines. The bigger spheres represent genes coding for proteins with known structure. Smaller spheres represent genes coding proteins for which no structural information is available.