Comparative data analysis: relevance for mouse in vivo and human primary hepatocytes.

<p>Publically available transcriptomics data (Gene Expression Omnibus) relevant for the actions of known PPAR agonists in mouse liver <i>in vivo</i> and human primary hepatocytes were used. The heat map represents significant gene sets (GSEA p<0.05, FDR<0.05), which were subjected to HCA. Gene sets were obtained using the ANNI text mining tool. Processes that were upregulated are represented by red colour, the downregulated processes are depicted in green, and unaffected processes are in black. Ale stands for aleglitazar (double PPARα/γ agonist), Pio/Feno-pioglitazone/fenofibrate (PPAR γ/PPARα agonists), Tesa-Tesaglitazar (double PPAR γ/α agonist), AMI-amiodarone (PPAR γ agonist), VA-valproic acid (triple PPARα/(β/δ)/γ agonist), TET-tetracycline, Wy-Wy14643, FO-fish oil, m-mouse, h-human, PCLS-precision cut liver slices, PH-primary hepatocytes, L- liver in vivo.