Rates of myocardial infarction per 1,000 persons per year (PY) in men under age 65 years and those age 65 years and older, in pre- and post-prescription intervals for an initial prescription for PDE5I with adjusted^* rate ratios (RR), and 95% confidence intervals (CI).

*<p>Adjusted for age and pre-existing medical conditions and medication use associated with MI or its risk factors (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085805#pone-0085805-t001" target="_blank">Table 1</a> and Supplemental Tables).</p>†<p>Effective sample sizes of PDE5I cohorts after weighting:</p><p>All Ages: 141,671.</p><p>Age <65: Years 121,696.</p><p>Age ≥65: Years 19,505.