Genome wide association analysis of hip dysplasia in Labrador retrievers.

<p>Genotypes of 17,859 SNPs were compared between 48 cases and 30 controls. A. Allele frequency based χ² statistics. The dotted line indicates the significance threshold after Bonferroni correction. B. Multiple testing correction of the χ² statistics by 1,000 permutations of the phenotypes to determine empirical p-values. The dotted line indicates the significance threshold (α = 0.05). C. Genome wide association analysis using Bayesian variable selection to detect SNPs with a high probability to have an effect on the CHD phenotype. The dotted line indicates the significance level.