d<sub>8</sub>-Taurocholate (d<sub>8</sub>-TCA) total (A) and cellular (B) accumulation in sandwich-cultured human hepatocytes exposed to ambrisentan, bosentan and macitentan.
- Eve-Irene Lepist (517179)
- Hunter Gillies (517180)
- William Smith (517181)
- Jia Hao (444898)
- Cassandra Hubert (517182)
- Robert L. St. Claire III (517183)
- Kenneth R. Brouwer (517184)
- Adrian S. Ray (120707)
Publication date
January 2014
DOIAbstract
<p>Bosentan and macitentan treatment resulted in a dose-dependent reduction in total accumulation of d<sub>8</sub>-TCA. Ambrisentan, bosentan and macitentan treatment each resulted in a dose-dependent reduction in cellular accumulation of d<sub>8</sub>-TCA. Data presented as mean (±SD) expressed as percent of control treated; n = 3 donors; *P<0.05 bosentan vs. control; # P<0.05 macitentan vs. control.</p
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