Prediction of transcription factors likely to have a role in placenta development.

<p>(A) For a library of 917 motifs, genome-wide binding site predictions were generated using the excess conservation method <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003449#pcbi.1003449-Wenger1" target="_blank">[7]</a>. The top 10,000 predictions for each motif were analyzed using GREAT <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003449#pcbi.1003449-McLean1" target="_blank">[8]</a> and TFs were ranked by significance of association with a placenta term. The top 50 TFs were further analyzed to determine if their role in placenta development has already been characterized. (B) The top 50 TFs most enriched for placenta terms, the TF DNA-binding domains, whether the TF is known to have a role in placenta development and the corresponding placenta term q-values.