Circulating PDC show decreased responses to SIV inversely correlated with the increased prevalence of Ki67⁺ pDC precursors.

<p>(<b>A</b>) Ki67⁺ pDC precursors counts during primary infection in the blood of 6 macaques, as a percentage of the total pDC population (<b>Top</b>) and as absolute counts (<b>Middle</b>), and dot plot showing increase of Ki67⁺ pDC in one representative animal from baseline to day 9 p.i. (<b>Bottom</b>). (<b>B</b>) Evolution of IFNα production per pDC in response to stimulation with 200 ng p27 equivalent of inactivated SIV (SIV-AT-2) for 24 h (n = 6). (<b>C</b>) IFN-I production per pDC in response to SIV-AT2 correlates negatively with the Ki67⁺ pDC counts.