Skin solubility determines maximum transepidermal flux for similar size molecules
- Zhang, Qian
- Grice, Jeffrey E.
- Li, Peng
- Jepps, Owen G.
- Wang, Guang-Ji
- Roberts, Michael S.
Publication date
June 2009
DOI Publisher
Springer Science and Business Media LLC ISSN
0724-8741 Citation count (estimate)
56Abstract
The maximum flux of solutes penetrating the epidermis has been known to depend predominantly on solute molecular weight. Here we sought to establish the mechanistic dependence of maximum flux on other solute physicochemical parameters
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