Scanning electron microscopy of <i>Leishmania amazonensis</i> promastigotes after treatment with MDL28170.

<p>In untreated, control promastigotes (A–C), note the elongated body and emerging flagellum. (D–I) Treatment with the IC₅₀ dose (D–I) and two times the IC₅₀ (2×IC₅₀) dose (J–M) of MDL28170 for 72 h caused shortening of the parasite body (E–H,J) and of the flagellum (arrows), membrane protrusions and ruffling of the plasma membrane (asterisks), appearance of cells with bizarre shape (D,K–M) and aggregation of cells (I).