Dose-dependent effect of resveratrol on infarct volume following transient ischemia/reperfusion.

<p>(A) Representative photomicrographs of TTC-stained, 1 mm thick coronal slices illustrating the extent of infarct within the prefrontal cortex following pretreatment (30 minutes prior to MCAO; i.v.) with either Vehicle (propylene glycol 4×10^−3% (v/v)) or Resveratrol (2×10⁻⁷ and 2×10⁻³mg/kg) following ischemia/reperfusion (tMCAO). (B) Bar graph summarizing the dose-response relationship between increasing doses of resveratrol and infarct size (mm³) calculated from TTC-stained, 1 mm thick coronal sections following tMCAO. Each bar represents the mean ± S.E.M. (n = 5–6/group) and <b>*</b> indicates significance (<i>p</i>≤0.05) from the vehicle-treated control group.