miR-10a targets HOXA1 in GC.

<p><b>a</b> The prediction of the binding between miR-10a and HOXA1 by Pictar. <b>b</b> HOXA1 protein expression in HGC-27 and MGC-803 cell transfected with miR-10a mimics. <b>c</b> HOXA1 mRNA level in HGC-27 and MGC-803 cell transfected with miR-10a mimics. <b>d</b> Western blot analysis of HOXA1 protein level in 24 GC patients. The left panel presents the expression of HOXA1 in 12 GC patients in whom miR-10a was down-regulated in their GC tissues (C) compared with the corresponding adjacent non-neoplastic tissues (N). The right panel presents the expression of HOXA1 in 12 GC patients in whom miR-10a was up-regulated in their GC tissues (C) compared to the non-neoplastic tissues (N). <b>e</b> Inverse correlation between HOXA1 protein levels and miR-10a expression in the above 24 GC patients.