HMGB-1 can affect retinal endothelial cell activity.

<p>(<b>A</b>) Expression of <i>CCL2</i> and <i>CCL5</i> chemokines, <i>IL-1β</i> and <i>IL-6</i> cytokines, as well as cell adhesion molecule <i>ICAM-1</i> in HMGB-1-treated (5 and 10 µg/ml) and control (PBS-treated) retinal endothelial cells. Gene expression was assessed using quantitative RT-PCR in cells exposed to HMGB-1 or PBS after 24 hours (*P<0.05, **P<0.01, n = 6). (<b>B</b>) Comparative analysis of chemokine and cytokine expression in HMGB-1 treated retinal endothelial cells.