Gene delivery of <i>Nr1d1</i> suppresses pan-retinal spotting, retinal dysplasia and function in <i>Nr2e3</i>^rd7/rd7 mice.

<p>(A–F) Fundus photographs of control and <i>rd7</i> injected retinas: (A) B6 (uninjected), (B) <i>rd7</i> (uninjected), (C) <i>GFP</i> injected, (D) <i>GFP.Nr2e3^B6</i> injected, (E) <i>GFP.Nr1d1^AKR/J</i> injected, (F) <i>GFP</i>.<i>Nr1d1</i>^B6 injected. (G–J) DAPI staining (blue) shows rescue of defects in retinal morphology 30 days after electroporation into <i>rd7</i> neonatal retinas. (G) GFP control, (H) <i>Nr2e3^B6</i> injected, (I) GFP control, (J) <i>Nr1d1</i>^AKR/J injected. L: left, R: right, GCL: ganglion cell layer, INL: inner nuclear layer, ONL: outer nuclear layer. Scale bar = 50 µm. (K, L) Representative scotopic (K) and photopic (L) electroretinograms from animals 4 month after injection with <i>GFP</i> (blue) or <i>GFP.Nr1d1^AKR/J</i> (red).