THPTS-PDT on retinoblastoma cell lines.

<p>In vitro cell survival analysis of WERI Rb-1 (A) and Y79 (B) cells irradiated with laser after incubation with THPTS (200 µg/ml) for 0.5 h, 1.5 h, 3 h, 6 h, 12 h or 24 h (red bars) showed a minimal survival rate of 0% –5% after an incubation time of 1.5 hours (WERI Rb-1) or 3 hours (Y79). When incubated with THPTS (200µg/ml) without irradiation (dark toxicity) for 0.5 h, 1.5 h, 3 h, 6 h, 12 h or 24 h (brown bars), the survival rate relative to control varied from 85.2% (3 h) to 107.7% (24 h) in WERI Rb-1 and from 100.0% to 141.1% in Y79. Laser irradiation alone (light orange bars) lead to no significant changes of the survival rates relative to controls.